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These results demonstrated the possibilities of modulating the release profile by means of the processing parameters rather than through the classical approach of altering the formulation.
However, it is interesting to note that in drug delivery research, there is acceptance that particulate matter can be absorbed from the gastrointestinal tract, and this feature of nanomaterials is being used as an approach of altering the pharmacokinetic behavior of drugs (Florence 2004).
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We therefore attempted to systematically determine the precise functional group(s) and their interactions responsible for the specific localization by following a "mutational approach" of systematically altering the various functional groups on the phenyl ring.
Metabolic oligosaccharide engineering is powerful approach to altering the structure of cellular sialosides.
A 5-year renal risk cutoff of 2.5% appears to give good sensitivity and specificity; it is, however, outside the scope of this study to specify therapy approaches, as the effect of altering therapy on outcomes as a response to a level of risk has not been studied.
No control group was used as it was deemed unnecessary because our aim was to explore the effect of isolated approaches to altering knee angles rather than test an 'intervention.' It is possible that alterations in dependent variables were due to other factors such as natural variation over time, measurement variability and not to the independent variables used in this study.
The possibility exists, therefore, of using this approach to alter levels of endocrine and paracrine factors.
In this study we report a bioinformatic approach to discover genes capable of altering GR function.
Given the evidence from sequence comparisons that selection serves to increase G+C contents in G+C-rich genomes, we adopted an experimental approach to test the effects of altering base compositions by assaying E. coli strains expressing genes of different G+C contents.
The diffusion of political power to regional parties, combined with coalition governments at the center, has already shown signs of altering India's approach towards its neighbors, for better and for worse.
These studies suggest that the up- or downregulation of one or more miRNAs would be a valid approach to alter expression of c-Myc, Cyclin D1, and Runx2 genes, thereby prohibiting breast cancer progression to bone metastasis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com