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While it is true that for alignment-based SNP detection it is arguable that we need only store BAM files for as long as it takes to calculate a result and that final output can be stored more efficiently than the reads, such an approach precludes the possibility of truly novel discovery that the De Bruijn graph approach makes possible and is also not amenable to easy re-analysis.
This hybrid approach makes possible to build a simulation-based expert system which supports the decision making for the acquisition of an underwater vehicle.
The classification approach makes possible the detection of macro-calcifications using second-order Gaussian derivative operators.
The approach makes possible the generation of a much larger number of specific scenarios based on limited user-supplied information.
The multicommutation approach makes possible the on-line dilution of a single standard to obtain the external calibration.
The proposed approach makes possible to explore and size heterogeneous and reconfigurable architectures according to expected system performances.
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This approach made possible, for the first time, the separation of N-cadherin/γ-catenin from N-cadherin/β-catenin complexes and the identification of multiple members of each of these isolated protein complexes.
This approach made possible the direct comparison of the simulated cellular phenotypes described by P in the model and the level of CD56 protein that describes the phenotype of the living cells.
An alternative approach, made possible by advances in machine vision and imaging technology, is to use a high-throughput, high-content assay to characterize behavior in detail and to survey known genes for behavioral phenotypes.
Importantly, all analyses were conducted blind to the identity of samples, an approach made possible by interrogating purified nuclei rather than cells or tissues that themselves show identifying increases of plaques and tangles in AD.
This review will highlight traditional approaches to the imaging of dendritic spines and newer approaches made possible by advances in microscopy, protein engineering, and image analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com