Exact(7)
The project, published today in the New England Journal of Medicine, reflects a new approach to the hunt for disease-causing genes an approach made possible by the plunging cost of DNA sequencing.
This approach made possible, for the first time, the separation of N-cadherin/γ-catenin from N-cadherin/β-catenin complexes and the identification of multiple members of each of these isolated protein complexes.
This approach made possible the direct comparison of the simulated cellular phenotypes described by P in the model and the level of CD56 protein that describes the phenotype of the living cells.
An alternative approach, made possible by advances in machine vision and imaging technology, is to use a high-throughput, high-content assay to characterize behavior in detail and to survey known genes for behavioral phenotypes.
Importantly, all analyses were conducted blind to the identity of samples, an approach made possible by interrogating purified nuclei rather than cells or tissues that themselves show identifying increases of plaques and tangles in AD.
The second approach, made possible by high-resolution mapping of hotspot positions across sequenced genomes (e.g., Gerton et al. 2000; Myers et al. 2005; Ptak et al. 2005; Winckler et al. 2005; Cromie et al. 2007), has been to search computationally for motifs that are nonrandomly associated with hotspots.
Similar(53)
The approach makes possible the generation of a much larger number of specific scenarios based on limited user-supplied information.
The multicommutation approach makes possible the on-line dilution of a single standard to obtain the external calibration.
The proposed approach makes possible to explore and size heterogeneous and reconfigurable architectures according to expected system performances.
This crowdsourcing approach makes possible to conduct information retrieval experiments extremely fast, with good results at a low cost.
A split-screen approach makes possible the viewing of both a word-processed document and a spreadsheet at the same time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com