Sentence examples for approach linkage from inspiring English sources

So a population initially in linkage disequilibrium will approach linkage equilibrium over a number of generations.

As a complementary approach, linkage disequilibrium (LD -based association mapping has been proposed as a fine mapping approach with potentiaLD -basedgle-gene resolution [ 8].

The candidate gene approach, linkage analysis, and association studies are all significantly more powerful with recent advances in genome mapping, sequencing, and analysis of individual variation.

Among the families we analyzed (a, b and c), the genotype phenotype discordance and the results of our combined approach (Linkage and WES studies) showing p.Cys169Tyr of Cx26 as the only causative variant, prompted us to further investigate its role.

However, average degrees of dominance estimated from F2 populations randomly mated for several generations to permit genetic recombination and approach linkage equilibrium were always smaller than the estimates from nonrandom mated F2 populations and usually in the partial to complete dominance range (Hallauer and Miranda 1981).

Complex trait dissection in many species has largely relied on two main approaches, linkage analysis with biparental populations and linkage disequilibrium analysis with association panels.

As this occurs more and more over successive generations, the LD decays, or approaches linkage equilibrium, when the marker and the mutation appear to be independent in the population.

The metabolic syndrome traits are known to have high heritability (30 70%), and candidate gene approaches, linkage studies, and genome-wide association studies (32) have identified susceptibility regions and loci for individual metabolic syndrome components.

This catalog constitutes a useful resource for detecting candidate genes controlling traits of interest and for the development of new genetic markers for forward genetics approaches (linkage mapping and QTL detection, association mapping) for dissection of the genetic architecture of adaptive traits [ 6- 9].

Using a quantitative approach to linkage analysis, Cardon et al. (1994) found linkage to a region of the short arm of chromosome 6 (6p22.2).

The most popular technique for investigating disease genetics over the last two decades has been an approach called linkage analysis, which involves looking at the relationship between inheritance patterns and genetic markers on chromosomes in families affected by an illness.