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Both the hypothetical and clinical example show that this approach is incorrect and can result in relevant residual confounding.
We clarify that this was due to the incorrect calculation of marginal predictions from a random intercepts model and explain intuitively why this approach is incorrect.
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We argue that the test statistics drawn from what we call the "standard" approach are incorrect.
This approach was incorrect, and the targeted power (at the p=0.05 level) should instead have been increased without altering the p-value threshold.
The disadvantage of this approach is that incorrect update decisions might later result in incorrect detection and that the uncovered background could be detected as foreground after removing static objects even if those do not get absorbed by the long-term model if the lighting conditions have changed notably.
One limitation of the current approach using literature mining technology is incorrect or missed identification of the mentioned targets within the literature.
If objective changes or the assumed utility function is incorrect, these approaches will fail.
Another issue is that of the "minimal genome": equating minimal genomes reconstructed by comparative-genomic approaches with ancestral life forms is incorrect and does not reflect the original view of the authors of the minimal genome notion (of which ref. 27 in the present manuscript is a proper reflection).
Third, sensitivity and specificity of the STRATIFY tool for falls, which were calculated by the standard approach, might be incorrect because falls might be recurrent and time-dependent [ 31].
Regardless, these strictly intracellular pathway engineering approaches will fail when the assumption is incorrect; that is, when molecular transport limits maximum production rates.
Plainly, this is incorrect.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com