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A third approach is computational de novo protein design, which has been used to make an enzyme that catalyses the Kemp elimination reaction, in which a hydrogen ion (H+) is removed from a carbon atom in an organic molecule (Fig. 1c 8.
The WL-RLS approach is computational more economical than the conventional RLS obtaining similar convergence speed and robustness.
The main advantage of the topological approach compared to the stationary state approach is computational speed.
In addition, the major challenge accompanying this broad approach is computational complexity, because too many differential gene expressions (probes) must be calculated.
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As a result, predicting wind behavior around naturally ventilated buildings has become important and one of the most common prediction approaches is computational fluid dynamics (CFD) simulation.
Experimental design approaches are computational techniques for extracting the most useful information from experiments yet to be performed [ 1].
Other structure-based approaches are computational very expensive and depend on solved structures, which in reality are very few [ 24, 25].
The approach used is Computational Fluid Dynamics (CFD) and foam geometries were schematically represented with tetrakaydecahedra geometries.
The study is limited, however, by the data preparation approach, which is computational prediction.
Therefore, the approach is both computational resource and energy hungry.
Therefore, the main detraction of using the Eulerian Lagrangian approach is the computational expense (Chrigui 2005; Mpagazehe 2013).
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