Sentence examples for approach in cell from inspiring English sources
The concept of statistical experimental design and multivariate evaluation was shown to be a useful approach in cell toxicity screening studies.
We demonstrate suppression of murine rhodopsin transcript by up to 90% with full concomitant expression of replacement transcript and establish the validity of this approach in cell culture, retinal explants, and mouse liver in vivo.
Therefore, this study investigated to identify new biomarkers and pathobiological role for PAHs exposure, especially BaP using targeted mitochondrial genomic and proteomic approach in cell line, peripheral blood/mesenchymal stem cell, and in vivo zebrafish model.
Similar results were obtained with a combination approach in cells that were inherently resistant to ABT-199 owing to their high MCL-1 and BCL-xL protein expression.
These studies prompted us to begin an integrated approach in cells isolated from human blood to establish a quantitative assay of mitochondrial function that will have the power to predict disease progression and response to treatment [ 9].
The use of this CEA enhancer promoter-based prodrug approach in cenhancer promoter-based CEA exprodrugn capproachduce suffinient cellstivity to convert 5-DFCR to 5-FU other than at very lowithvelow(Richards et alevels5b).
Using transgenic and antisense approaches in cell lines, these pathway alterations should then be induced and the predicted development into a DD cellular phenotype tested.
The strongest causal evidence is obtained with transgenic approaches, in cell culture or animal models, to identify phenotypes triggered by such variations [ 21, 22].
Downmodulation of CD146 expression by siRNA or shRNA approaches in cell lines that spontaneously express a high level of CD146 mostly resulted in a decreased migration in three distinct assays, at least one of which involves heterotypic cell cell interactions.
Genetic and pharmacologic approaches in cell culture and in vivo allowed us to conclude that maintenance of a proper RARαβ/γ balance is crucial for preserving normal epithelial cell homeostasis.
Therefore our results may lead to novel approaches in cell seeding to develop vascularized bone tissue engineered scaffolds, such as selective, prioritized, or time dependent seeding of different cell types.
