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Interestingly two separate groups of investigators, using an in vitro screening of a phage display library approach, have identified the exact same sequence as CTP, and shown it to have high affinity for binding to apatite-based, bone-like minerals [14] and two specific sulfated carbohydrates [15].
A recent study using a combined bioinformatic and high-throughput experimental approach have identified 53 miRNAs not conserved beyond primates[ 10].
Several recent reports using comparative genomics approach have identified conserved non-coding regions among different vertebrates [ 14- 16] but none to the degree that we report here.
Previous studies, most of which employed a candidate gene approach, have identified a number of genetic variants showing GxE with n-3 PUFA on T2D-related traits [ 6, 7].
Additionally, several studies using this approach have identified some miRNAs and explored the roles of miRNAs in root development in Medicago truncatula [ 17], maize [ 18, 19], rice [ 20] and potato [ 21].
Metagenomic studies employing a case-control association discovery approach have identified associations between inflammatory bowel disease and Enterobacteriaceae [ 83], colorectal carcinoma and Fusobacterium[ 35], and type 2 diabetes and butyrate-producing bacteria [ 14, 84].
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This approach has identified several kinases that modulate the cell metabolome following infection.
As a result, our comprehensive, unbiased analytical approach has identified a diverse set of specific defective biological pathways that contribute to the underlying aetiology of the ASDs.
Using this approach has identified two lead PET compounds, 18F-SIG343 and 18F-SIG353.
This approach has identified 2-aminopyridine-3-carbonitriles as the first multi-target ligands at A1R, A2AR and PDE10A, by showing agreement between the ligand and structure based predictions at these targets.
This approach has identified a number of differences in innate and acquired immunity between susceptible and resistant strains [8] [18].
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