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This promising platform technology provides both a research tool capable of probing the effects of local gene silencing and a potentially high-impact therapeutic approach for sustained, local silencing of deleterious genes within tissue defects.
Biodegradable polymer coating can be very effectual drug delivery approach for sustained and controlled delivery by preventing burst release kinetics.
As an alternative, learning from nature, we chose to develop a biomimetic approach for sustained release of fMLF in vivo.
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The rationale is that since natural forest ecosystems and their dynamics are able to sustain the whole range of forest-dwelling species and forest functions, silviculture that mimics natural dynamics should be a good approach for sustaining forest biodiversity (Schütz et al. 2012).
San plat training over provision also appears to be another cost-effective approach for sustaining sanitation coverage.
Our results presented here further support the notion that a locked nucleic acid-based inhibition of miR-494 may provide a promising approach for sustaining sufficient expression of TET protein and multiple invasion-suppressor miRNAs as a novel therapeutic strategy against HCC vascular invasion and recurrence.
Although holistic approaches for sustaining the physical attribute of large forest ecosystems have been advocated, attention has yet to focus on complementary organizational landscapes composed of integrated and co-ordinated public agencies.
As a result, if heads must be restricted at many locations, or there are many pumping cells, the embedding approach is preferred to the response matrix approach for computing sustained yield groundwater pumping strategies for confined aquifers.
We envision this biomimetic approach for the sustained, localized and in situ generation of ROS could provide new opportunities for wound management by protecting against pathogen infection and potentially even enlisting ROS-mediated wound healing mechanisms.
The pod-IVR design enables the vaginal delivery of multiple microbicides with differing physicochemical properties, and is an attractive approach for the sustained intravaginal delivery of relatively hydrophilic drugs that are difficult to deliver using conventional matrix IVR technology.
In principle, such an approach can be used for sustained, local therapeutic protein release to inhibit tumor growth.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com