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To explore an approach for rational heme protein design, we herein rationally introduced a pair of cysteines (F46C/M55C) into the scaffold of myoglobin (Mb), mimicking those in native neuroglobin.
The establishment of periodic trends is a powerful approach for rational design of heterogeneous catalysts.
By combining MD simulations and AFS experimental technique, we demonstrated a powerful approach for rational design and single molecule testing of novel inhibitor molecules which can block amyloid-amyloid binding – the first step of toxic amyloid oligomer formation.
Considering the abundant Fe resources and its low cost, the Fe(III -cocatalyst modIII -cocatalyste regarded as an effective approach for rational design and developmodification-performancanvisibee-light photocatalysts in pregarded asplicanions.
Our results show that PLGA-based lipopeptide delivery is a promising approach for rational design of a simple, effective and patient friendly intranasal GAS vaccine resulting in mucosal IgA response.
So far, however, the available examples of DNA aptazyme sensors are still limited in utilizing only several DNAzymes and DNA aptamers, most likely due to the lack of a general and simple approach for rational design.
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The findings presented here are expected to provide new approaches for rational design of nanosized Ni Al2O3 catalysts for CO methanation reactions in slurry phase.
However, a grand challenge still exists in developing facile and generalized approaches for rational design and fabrication of them in large scale.
Combining (i) genomic, tissue engineering and regenerative medicine approaches for rational design of mouse models with (ii) rapid prototyping and computational benchmarking against human clinical data will enable fast and nonbiased validation of newly generated models.
Traditional approaches for rational drug design used the "one gene, one drug, one disease" paradigm to design exquisitely selective ligands of a single disease target.
Nevertheless, further elucidation of the roles of discrete transcription factors in the CREB3 subfamily in cellular transformation might derive new approaches for rational design of targeted anti-cancer agents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com