Sentence examples for approach for linkage from inspiring English sources
We believe our simulations establish LOCate as a valuable complementary approach for linkage analysis of categorical traits, particularly nominal traits.
NN have not been widely accepted by the field as a valid approach for linkage analysis.
Here we validate the X-QTL approach for linkage analysis of a biomedically important trait (oxamniquine (OXA) resistance) in the human blood fluke Schistosoma mansoni for which the causative gene (Smp_089320 on chromosome 6) is now known [ 10].
Pe'er et al. (2008) estimated the multiple testing burden in GWAS through simulation studies using data on the HapMap ENCODE regions to emulate an infinitely dense map, analogous to the Lander and Kruglyak approach for linkage analysis (Lander and Kruglyak 1995), and arrived at the commonly accepted genome-wide significance threshold of 5 × 10−8.
Compared with traditional approaches for linkage analysis (i.e. Elston Stewart and Lander Green algorithms), our algorithm is essentially quadratic in terms of the number of typed individuals and linear in terms of the number of markers.
Compared with traditional approaches for linkage analysis, our new model can efficiently infer IBD status without enumerating all possible genotypes and transmission patterns of untyped members in a family.
The aim of this study was to compare the variance component approach for QTL linkage mapping in half-sib designs to the simple regression method.
While evidence supports that behavioral and cognitive interventions can be effective for improving ART adherence in sub-Saharan Africa [ 31, 32], few studies have rigorously evaluated approaches for increasing linkage to HIV care in high-prevalence regions [ 31].
Using our haplotype extension of the approach for joint modelling of linkage and association, analysis of 304 ASP families revealed no evidence of linkage unaccounted for by the association of type 1 diabetes with the +1140A/C −23 HphI haplotype (P = 0.28).
Analysis of 437 ASP families genotyped for −23 HphI, using the approach for joint modelling of linkage and association with conditioning on parental genotypes Li-cpg), provided no evidence of linkage unexplained by association with this variant (P = 0.31).
Cluster analysis will be used to group data (hierarchical approach using Ward's method for linkage).
