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This represents a novel approach for future development of inhibitors of PCSK or other enzymes.
In addition, Wu et al. (2015) proposed a multi-scale, transdisciplinary approach for future development of Inner Mongolia, guided by landscape sustainability science and land system design.
On intravenous administration into a neuroblastoma xenograft mouse model, nanovesicle complexes were found to distribute throughout the tumour interstitium, thus providing an alternative safer approach for future development of tumour-specific therapeutic nucleic acid interventions.
These systems provide an exciting, modular platform that improves the pharmacokinetic properties of the therapeutic, reduces bolus release of drug from nanoparticles, and enhances the safety and circulation half-life of the drug in vivo, proving them to be highly clinically-relevant and a promising approach for future development of molecularly-targeted and combination therapeutics.
Additionally, this can establish an objective approach for future development and research.
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This approach can be used for future development of high throughput screening of novel GSIs and other therapeutic leads for the treatment of AD, leukemia, and other diseases.
This experimental approach may have important implications for future development of point-of-care diagnostics, treatment monitoring, and testing of new TB therapeutics.
Given the relatively large number of published crystal structures of CRL1Skp2 components individually or in complex with other proteins (Supplementary Table S1), we propose that a structure-based drug design approach would be particularly attractive for future development of potent inhibitors.
The present approach may offer an alternative platform for future development of green-chemistry compatible bimetallic nanocatalysts.
This combined molecular and mathematical approach shows promising and informative direction for future development.
We anticipate that the approach appears to be a strong candidate for future development because of its scalable nature, environmentally-friendly process and relatively low cost.
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