Authors were approached for copies of questionnaires of interest.
An interesting approach for predicting copy number variants was suggested by Yoon et al. (2009), where GC content is used to normalize data.
In this study we applied the extreme groups/selective genotyping approach for identifying copy number variations in high and low fertility breeding boars.
However, the use of SNP arrays processed by ASCAT is an established approach for determining copy number profiles; therefore, a positive agreement between these two platforms would confirm the performance of Sequenza.
One potentially versatile approach for single-copy BAC transgenesis is to introduce BACs into the genome via DNA-type transposons.
Statistical approaches for analyzing copy number data are aimed at detecting the regions of genomic alteration.
Because we analyze interval data, rather than probe data, our approach is readily applicable to microarray or high-throughput sequencing approaches for measuring copy number.
This method is similar to the read depth approaches for detecting copy number variants, which assume a Poisson distribution in mapping depth and therefore detect duplications and deletions by searching for regions with significantly higher or lower read depth [ 24, 25].
Exome capture may also be a promising approach for finding common copy number association with disease.
Comparative Genomic Hybridization (CGH) is a molecular approach for detecting DNA Copy Number Alterations (CNAs) in tumor, which are among the key causes of tumorigenesis.
