Exact(9)
Although more samples and markers are needed for verification, these preliminary results suggest that our network and pathway-based approach for candidate gene selection might be promising.
Our approach for candidate gene identification can be extended to any other species with reference genome.
Genetic interaction screening in tractable model organisms constitutes a powerful alternative approach for candidate identification.
The Approach for Candidate Gene Retrieval (ACGR) presented in this article is inspired from this last group of methods.
Gene resequencing studies have clearly been proven to be a fruitful approach for candidate cancer gene discovery.
A system called ACGR (Approach for Candidate Gene Retrieval) has been implemented and tested with three case studies including a rare orphan gene disease.
Similar(51)
In fact, there is a general lack of systematic approaches for candidate SV analysis.
In addition, many computational scientists focus on the development of novel generic approaches for candidate gene prediction for diseases in general.
The other known systems biology approaches for candidate gene prediction are based on direct protein-protein interaction of the gene that is being studied [ 4- 6, 39].
With increased availability of tools and approaches for candidate gene validation, many more QTL are being successfully identified at an increasing pace (Dipetrillo et al. 2005, Flint et al. 2005).
It is important to note that network based approaches for candidate disease gene priortization need to be viewed with care as the map of the binary human PPIN is still incomplete.
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