3) An in silico analysis of the biological significance of the results obtained with our PLS approach and pathway analysis indicates that processes related to protein degradation and cell death perhaps initiated by oxidative stress are likely involved in colorectal cancer.
Identifying components of good practice that apply to several marginalised groups may prove to be a useful way for guiding the development of services, since care systems struggle to provide very different approaches and pathways for each group.
To compare the performance of different approaches, we computed the PPV values by calculating the ARI scores between identified pathways from each approach and the pathways from Reactome, KEGG and BioCyc.
The approach employed and pathways identified by this study may facilitate therapeutic research aimed at discovery of drugs and drug targets.
One the other hand, from a biotechnological point of view, the organism can be used for genome mining approaches and pathway engineering towards medically relevant rhizoxin derivatives.
Bioinformatics analyses of differentially expressed proteins were performed by means of Gene Ontology, metabolic pathways, transcriptional regulation networks using Blast2GO software, the Dynamic Impact Approach and Ingenuity Pathway Analysis.
With the help of significant proteins identified by the proposed network-based biomarker approach and the pathway information, it is possible the multi-target therapeutic interventions that act on different critical pathways in lung carcinogenesis can be developed.
The R-package Pathview 19 finally has a broader approach and creates pathway visualizations from additional data types like genomic variation, literature record, and metabolite level.
However, such a method should be coupled to a text mining approach and a pathway database which is beyond the scope of this study.
This low percentage, however, is still significantly greater than that found purely by chance (Z-test, P < 0.001) with regard to the similarity between the pathways discovered by our approach and the KEGG pathways.
