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Our approach also identified alliances and associations that are near their distributional limit or where the study area is a stronghold of their distribution, indicating distinctiveness.
Whereas the first approach also identified a large fraction of cytosolic proteins - either membrane-associated or cytosolic contaminations - membrane shaving only revealed proteins with 1 to 21 trans-membrane domains.
Our 2D LC-MS/MS approach also identified Transferrin Receptor 1 (P02786 Swiss-Prot), NICE-4 (Q14157 Swiss-Prot), Plectin 1 (Q6S383 Swiss-Prot), and Thymopoietin (P42166 Swiss-Prot) as poThymopoietin binding P42166ns, but direct co-IP experiments indicated thas these were non-spotentialinding proteins (data not shown).
Despite this, our approach also identified 18 methylated proteins with half-life less than 60 minutes.
In our case, the GWAS approach also identified a substantially lower number of associations than LDLA.
Our approach also identified novel viral genes in both KSHV and EBV, and extends viral genome annotation.
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However, this approach also identifies "false positive" genomic regions that preferentially appear in the IP sample due to artifactual association with the agarose beads and/or the antibody (or something in the antibody preparation).
Our approach also identifies some genes that are not indicated by others.
Our approach also identifies new signaling components involved in the release of cytokines, including Ribosomal S6 kinase on TNFα.
However, this approach also identifies genes other than those required for virulence and both STM and IVET identify genes in a pathogen that are also present in non-pathogens.
The information theoretic approach also identifies RSK, a substrate of ERK [ 95], as a potentially novel regulatory component involved in the release of TNFα.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com