The results from the evaluation by two physicians according to speciality are provided in Table 6, reflecting the divergence in physicians' medical appreciation of medication errors and their clinical consequences.
Such a strong appreciation of medication by both physicians and patients may originate from the tradition of ancient Japanese medicine, in which medication was the primary treatment and medical practitioners were often considered to be pharmacists [ 23].
From the patients' perspective key deficits have been identified in their illness understanding, knowledge of the medicolegal aspects of mental healthcare and their awareness and appreciation of medication choices and side-effects.
Before the start of nilotinib treatment and after 3, 6 and 12 months, patients are asked to fill in a comprehensive questionnaire including topics on quality of life, side effects, attitude towards disease and medication, the patients' appreciation of information received about the medication, and discontinuation, and trough plasma levels of nilotinib are measured.
Patient experiences with drug use is assessed by means of a comprehensive questionnaire including topics on quality of life, side effects, attitude towards disease and medication, and the patients' appreciation of information received about the medication.
The questionnaire at 3, 6 and 12 months includes non-prescription medication, quality of life, attitude towards disease and medication, side effects, adherence by means of the MARS, the patients' appreciation of information received about the medication, discontinuation and questions upon experiences with and opinions on the DBS.
Further, there is a lack of evidence-based individualized goals and strategies combining lifestyle and medications, or appreciation of sequential (stepped) therapy.
Interactions do not always represent contraindications for use, but knowledge and an appreciation of them before prescription is essential for the safe use of medication.
For example, a better appreciation of patients' experiences with a particular medication's side effects or inconveniences may lead physicians to optimize dosing or review administration instructions with their patients.
Only since the 1990s has there emerged an appreciation of the effects of atypical antipsychotic medications, which can be beneficial for the negative (cognitive) symptoms via combined action at dopamine as well as serotonin and other classes of neuroreceptors [1].
