We lack a comprehensive understanding of the exact mechanisms (both on- and off-target) by which drugs exert anti-cancer effects in vivo; this is exacerbated by our incomplete appreciation of networks, cross-talk and redundancy in cell signalling.
At the CBS upfront, Dan Rather offered somber words of appreciation for the network's news division.
Though in comparison with the AT&T iPhone, the Verizon iPhone won glowing appreciation for its network reliability and voice quality, as reviewers at Engadget and Wired have noted, Verizon's data speeds are noticeably slower.
Hearts are a simple, universally understood, way of showing appreciation on social networks, while the username feature just highlights the creator's username so it stands out.
To gain a better appreciation for the network-level patterns that might be driving the identified functional alterations, we constructed a gene-by-TF matrix of the t-statistic values associated with the differences in edge weights predicted for the female compared to the male sputum networks and performed a complete-linkage hierarchical clustering using a Pearson correlation coefficient distance.
An appreciation of the complex network that leads to these cellular and inflammatory responses will form a foundation on which to develop therapeutic interventions to combat inflammatory periprosthetic bone loss.
Real-time observations of microtubule dynamics in axially growing cells, in combination with analysis of phospholipid regulation of cytoskeletal organization, have provided a deep appreciation of the regulatory networks involved in cytoskeletal organization (Lin et al., 2014; Pleskot et al., 2014).
We are optimistic these mutations, and new ones that will be identified in the future, will constitute a novel and solid foundation for enhanced appreciation of how signaling networks are perturbed in cancer and other diseases.
Especially on the business interruption side, companies and underwriters are starting to gain a greater appreciation for the consequences of network outages and corresponding revenue loss.
Eisenhower gained an appreciation of the German Autobahn network as a necessary component of a national defense system while he was serving as Supreme Commander of the Allied forces in Europe during World War II.
