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The spatial engagement of PQC factors, including both chaperones and components of the ubiquitin proteasome system, is a newly appreciated consequence of their function in vivo.
Another recently appreciated consequence of oxidative stress is the induction of endoplasmic reticulum stress, which links it to inflammation, with significant implications for several disorders including cancer [ 16, 17].
Another, potentially less appreciated, consequence of performing multiple underpowered subgroup comparisons is that readers can be misled into believing that these negative results provide reliable evidence that the treatment is similarly effective in all patients, potentially masking important subgroup effects owing to inadequate power.
Similar(56)
And, it will require a deliberate system of checks and balances to channel the narcissism, arrogance, short-termism and failure to fully appreciate consequences that have bedeviled human endeavors for thousands of years.
The president and his advisers may not have appreciated the consequences of their decisions.
It is unclear if Morgans' management appreciated the consequences of handing this degree of control over the company to Mr. Burkle's Yucaipa.
By doing all these things the modernists demonstrated they fully appreciated the consequences of Einstein's discoveries.
In all, it appeared the audience really appreciated the consequences of altering basic elements and having some agency in the process.
While the potentially devastating effect of rising mean temperatures on sex ratios in TSD species is appreciated, the consequences of increased thermal variance predicted to accompany climate change remain obscure.
Further explorations with spatially explicit models will be required to fully appreciate the consequence of land use change and altered disturbance regimes on patterns of species distribution and the maintenance of diversity.
For many, this is the first time their choices have had real consequences, and getting them to appreciate the consequences of large choices must start with small ones.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com