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Notably, the Ep-derived factors did not appreciably activate pulmonary macrophages.
These data suggest that HER3 does not appreciably activate PI3K in these cells.
In all cases, IFNγ did not appreciably activate ERK and STAT3, but yielded highest level of STAT1 phosphorylation (2441 ± 2073% of OSM level (Fig. 4E & 4F).
Under normal conditions, the total S1P in the plasma is quite high (300 500 n M); however, it has been hypothesised that most of the S1P may be 'buffered' by serum proteins, particularly lipoproteins (e.g., HDL>LDL>VLDL) and albumin, so that the bio-available S1P (or the free fraction of S1P) is not sufficient to appreciably activate S1PRs (Murata et al, 2000).
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Thus, promoters without their cognate sugars cannot be appreciably activated by non-cognate sugars.
Comparing life stage:adult sensitivity results for the metabolically activated versus direct-acting compounds can shed light on whether the previous results, including the relevant dosimetry, are likely to have been appreciably distorted by immaturity of metabolic activating systems in the neonatal period.
Consistent with the inability of oleate to activate caspase 9, oleate did not appreciably redistribute cytochrome-c to the cytosol (Fig. 5).
The degree of reaction of fly ash when activated with alkaline solution was found to increase appreciably with increase in curing temperature.
Importantly and unlike traditional antiretrovirals, viral decay accelerators are also predicted to have an impact on the population of latently infected cells, since latent HIV-1 infected cells are activated at low levels and virus reservoirs can be reseeded [36] [38], albeit very slowly or possibly not appreciably in strongly adherent subjects [39].
Pulis appeared appreciably happier.
His nose was appreciably thinner.
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