The probe displayed many desired properties such as high specificity, appreciable solubility, desirable response time and low toxicity to mammalian cells.
In the 86 patients who underwent invasive coronary angiography (CAD defined as >50% stenosis),F-flurpiridaz PET had superior sensitivity (78.8 versus 61.5%, resp., P = 0.02) and no appreciable difference in specificity (76.5% versus 73.5%, resp).
Our findings show compelling evidence that through charge flux analysis of the multiconductive ion-channel activity of Hsc70, we can quantitatively detect milli- and micromolar concentrations of ATP with appreciable sensitivity, selectivity, and high specificity.
Identifying quality of life score cut-offs able to detect high levels of HCNs or low levels of Sat at an appreciable degree of sensitivity and specificity would be useful but would not solve the problem to have valid and reliable instruments for HCNs and Sat assessment.
In contrast, Guha and Schürer did not obtain an appreciable difference in the sensitivity (or specificity) when adding 10,000 non-toxic compounds to the training set [11].
It has relatively high specificity for Met, with no appreciable inhibition of the activity of 229 other kinases tested.
No appreciable loss of immunoreactivity was observed and binding specificity was comparable to that of the unconjugated MAb.
Optimal hybridization conditions under which there was no appreciable cross-hybridization with the control spots were ascertained to maximize specificity and sensitivity.
The OD450 values obtained for SiHa cells expressing M2N and M2SD were respectively 58% and 33% of control, whereas no appreciable decrease of the OD450 values was observed in C33A cells, confirming the specificity of the results.
Subsequently, IC50 value was calculated for each cell line showing appreciable variations (from 4.54±0.66 μ to 30.47±6.75 μ) and indicating a certain cell-type specificity of malten activity.
