Sentence examples for appreciable restriction from inspiring English sources

While another substitution at CA110, A110R, leads to strong potentiation of N-tropism in murine cells, in the absence of additional mutations, we found that A110R alone was not sufficient to confer appreciable restriction in Ref1-expressing cells, despite the fact that authentic N-MLV shows strong restriction in those cells.

However, lowering the levels of intracellular cholesterol in A549 cells using methyl-β-cyclodextrin (MβCD) or lovastatin resulted in no appreciable difference in restriction of IAV WSN/33 by IFITM1 or IFITM3, with or without AmphoB treatment.

Modulation of cholesterol levels had no appreciable effect on IFITM3-mediated restriction, suggesting that cholesterol mislocalization does not contribute to VAPA's antagonism of IFITM3.

Whether these restrictions led to appreciable bias is unknown.

Although the PROGINS is unlikely to represent appreciable susceptibility risk factor, given the restriction of the association to endometrioid histology, the magnitude of the observed odds ratio, and the modest allele frequency of this variant, further analysis of this gene with regard to the endometrioid subtype is warranted to provide insight into the mechanisms underlying disease aetiology.

Our data demonstrate that the improvement in insulin sensitivity, as measured by HOMA-IR, precedes appreciable weight loss and is largely achieved with caloric restriction.

No difference in reactivity between MHC loaded with p*AA syn or with p*AA syn / anti was observed, which implied that the conformational restrictions in the MHC peptide binding groove have no appreciable influence on cleavage of the conditional peptide.

Secondly, CST between wildlife and livestock for diseases such as tuberculosis and brucellosis has appreciable economic impacts in agriculture by reducing livestock productivity and imposing export restrictions (Gortázar et al. 2007).

The SC decoy-DNAs inhibited the function of the restriction endonuclease, AatII, in a sequence-specific and concentration-dependent manner with an appreciable IC50 value (1.3 μM for SC.DD, 0.016 μM for SC.SD, 0.002 μM for SC.SS).

There are several reasons for this: the effects of sodium restriction on blood pressure in clinical trials have been variable; the extent of sodium deprivation required for an appreciable antihypertensive effect is uncertain; 37 the need for dietary changes can be bypassed by inducing sodium loss with a diuretic.

They have no appreciable gravity.