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A sufferer subgroup of 551 patients who warranted treatment for RLS was identified on the basis of at least twice-weekly symptoms with appreciable negative impact on QOL.
Treatment burden and adverse effects can have an appreciable negative impact on patients' quality of life (QOL) with prior studies showing that interventions with a high treatment burden for treating glucose (glycemic disutility) may substantially attenuate benefit as measured by quality-adjusted life-years.
Similar(58)
A 2010 study showed that nearly half of the guns that crossed state lines before being recovered in crimes came from just ten states, most with comparatively weak gun laws, indicating that weak gun laws in other states have already had an appreciable negative public safety impact on states like New York.
A negative impact?
And can they have a negative impact?
This attitude has a negative impact.
But will the slogan have negative impact?
"This could have a significant negative impact".
It has an incredibly negative impact.
This has a serious negative impact.
"McDonald's could have a negative impact.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com