Sentence examples for appreciable difficulty from inspiring English sources

Thus, sphincterotomy carries an appreciable difficulty and risk of retroduodenal perforation in such cases.

Some patients with a fused wrist have appreciable difficulties with activities of daily living (Sauerbier et al. 2000).

In spite of the criticisms of areal or ecological studies, it has to be recognised that case control studies involve appreciable difficulties in the selection of suitable controls.

We appreciate its difficulties.

By the mid-1960s, Poland was starting to experience also economic difficulties and the appreciable thus far standard of living improvements were showing signs of stagnation (during 1960 70 real wages for workers grew only by an average of 1.8% per year).

It is also important to know whether recent changes to the structure of postgraduate training, with a requirement for doctors to choose specialties early, accompanied by what may be seen as reduced flexibility, really do create difficulties for an appreciable proportion of doctors.

Considering the difficulty in collecting an appreciable number of cases with PJI for a study, the relatively large number of patients (n = 189) in our cohort should be sufficient to overcome potential bias.

One of the most intractable problems faced in immunohistochemical studies of Armadillo concerns the difficulty of unequivocally showing that it accumulates to any appreciable levels in the nucleus upon signalling.

The major difficulty in designing oligonucleotide probes for Actichip arised from the appreciable number of highly similar genes found in the actin cytoskeleton gene family [ 32].

A difficulty with the spraying of steel on copper is the attainment of appreciable thickness of the coating due to debonding during the thermal spraying process.

In a "closed" universe, the beams eventually cross; in an "open" universe, they spread apart.The difficulty with testing this by experiment is that the light beams must traverse an appreciable fraction of the universe before the deviations become significant.