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The phrase "appreciable difference between" is correct and usable in written English.
It can be used when discussing a noticeable or significant distinction between two or more items, concepts, or situations.
Example: "There is an appreciable difference between the two models in terms of performance and efficiency."
Alternatives: "significant difference between" or "notable difference between".
Exact(49)
Complementary NMR unfolding experiments with CαHα spy nuclei did show the unfolding effect, however the thermodynamic parameters obtained were different from N H observations and there was no appreciable difference between group 1 and group 2 residues (see the Supporting Information, Table S2 and Figure S20 30).
To his surprise, he could find no appreciable difference between treating depression with antidepressants and treating it with entirely different drugs, including tranquilizers and barbiturates.
Is there really any appreciable difference between one pair of synchronized divers and another?
Exit polls showed little appreciable difference between Mr. Obama's performance among black voters nationwide and in many swing states in this election and in 2008.
As fast as its autofocus has gotten, you may not notice an appreciable difference between it and competitors like the Nikon 1 or the Panasonic Lumix G3.
What appears to be a tied race in national polls, as I mentioned, could fairly easily be a two-point lead for Mr. Obama just based on statistical variance alone, in which case there would be no appreciable difference between the national polls and the polls in the tipping-point states.
Similar(11)
In our research we were able to discern no appreciable differences between the responses from participants in the different SES post code areas.
But the incident has added to uneasiness about whether society is prepared to handle the consequences of science that may eventually reveal appreciable differences between races in the genes that influence socially important traits.
Turnaways did, however, suffer from higher levels of anxiety, but six months out, there were no appreciable differences between the two groups.
Only part of the 3HB showed appreciable differences between the two structures (Fig. 1D).
A well-designed facial prosthesis has obvious benefits, but there were no appreciable differences between the two groups.
More suggestions(17)
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noticeable difference between
discernible difference between
demonstrable difference between
tremendous difference between
considerable difference between
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sizeable difference between
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appreciable association between
appreciable disparity between
appreciable lag between
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com