From these figures, we can see that the intensity ratios of D/G are not increased by stretching, indicating that stretching does not introduce appreciable defects.
However, because neither J.Vav cells nor Vav1−/− T lymphocytes show appreciable defects in TCR-induced actin polymerization (Fig. S1 and data not shown), we reasoned that the requirement for GEF activity must be conclusively addressed in T cells in the VavNULL background.
Although Gas1-LacZ expression in the GI system is detected early, we did not find appreciable defects in the gut tube at E10.5 and E11.5.
Thus, none of the single iron transport system mutants of Shigella displayed appreciable defects in intracellular multiplication or cell-to-cell spread, although a mutant deficient in three distinct iron uptake systems failed to replicate within epithelial cells.
Previously we demonstrated that a mutant A/WSN/33 (H1N1) influenza virus with defective M2 ion channel activity did not show appreciable growth defects in cell culture, although its growth was attenuated in mice (T. Watanabe, S. Watanabe, H. Ito, H. Kida, and Y. Kawaoka, 2001, J. Virol. 75, 5656 5662).
Again, no appreciable transthiolation defects were observed for the mutants, supporting the notion that the ubiquitin-binding surface is not involved in the upstream steps of the enzymatic cascade.
By promoting the initiation of shear bands and hindering their instable propagation through introducing artificial defects, appreciable macroscopic tensile plasticity was successfully achieved in a conventional Zr-based BMG.
All implants induced bone resorption, which lead to tear drop-shaped bone defects at 3 weeks post-operative, as opposed to no appreciable change in control defect dimensions.
We analyzed plates made in different laboratories and incubators in different buildings and never saw an appreciable difference in basal defect rates.
In contrast, a corresponding depletion of Cdt1 had no appreciable effect, and DNA replication defects were still only minimally evident after 8 hours of further reduction.
