The phrase "appreciable changes to" is correct and usable in written English.
It can be used when discussing significant or noticeable modifications made to something, such as a plan, project, or system.
Example: "The recent analysis revealed appreciable changes to the project's timeline, which will affect our overall strategy."
Alternatives: "significant changes to" or "notable changes to".
Therein, the chemical compositions of the nanostructured photoelectrode surfaces were observed to significantly change when the glass powder Si atoms became chemically bonded with the Ti atoms on the photoelectrode surface without appreciable changes to the crystalline structure of TiO2.
The pilot indicated that no appreciable changes to protocol or data collection procedures were required and the ten pilot patients were included in the overall analysis.
When cultured in TNF-α, the G3-expressing MC3T3-E1 cellshowedenhancedcellcell apoptosis induced by TNF-α, and expressed increased expression levels of pSAPK/JNK without appreciable changes to GSK-3β (S9P) expression.
The steady-state solvatochromic studies show no appreciable change to the charge transfer of BMVC by substituting an anisole electron-donating group at 9-position of BMVC.
The results also show that the primary effect of sulfur doping is to lower the mass burning rate of the fuel in direct correlation to the Shore-A hardness of the material which increases the time to ignition with no appreciable change to the mean autoignition temperature.
For HCh and FYI, there is similarly no appreciable change to the subgraph connectivity profiles upon random removal of up to 15% of edges but the profiles do change upon random addition of edges.
Downregulation of Sox2 using siRNA did not result in any appreciable change to the levels of ALK, p-ALK, STAT3 and pSTAT3 (data not shown).
They found no appreciable change to the AUC after the addition of the 8 SNPs (AUC changed from 0.833 to 0.839), which they suggested may have been partly due to lower risk allele frequencies in their Greek population compared to other European populations [ 18].
As is expected the density of light water does not show any appreciable change due to the very small quantity of deuteriated water at the 1 - 150 ppm level.
While ribosomal genes do not exhibit appreciable changes in response to environmental alterations (Müller and Wittmann-Liebold, 1997; Itoh et al., 1999; Wolf et al., 2001), tRNA genes may provide an important source of evolutionary plasticity for fine tuning translation.
It seems unlikely that secular or cohort changes extending over one or two decades in exposures would lead to appreciable changes in these variables.
