Exact(1)
DOI: http://dx.doi.org/10.7554/eLife.02872.015 The Rb gene is transcribed and spliced into a single 4.7 kb mRNA composed of 27 coding exons that does not undergo appreciable alternative splicing and encodes a single 105 kDa protein (Burkhart and Sage, 2008).
Similar(7)
Our results predict that this effect only comes into play at sustained growth close to the long-term starvation limit, and only when there is no appreciable level of alternative substrates present.
The appreciable level of alternative splicing indicates that the exon 5 is poorly defined, very likely because of the presence of a weak 5′ss.
Conversely, the lack of an appreciable effect would suggest that alternative strategies are needed.
Single Nucleotide Polymorphisms (SNP) are the most common type of genetic markers and refer to a position where two alternative bases occur at appreciable frequency (>1%) in a population [1].
The exploitation of lignocelluloses materials including agroindustrial waste may hence serve as effective and cheap alternative in producing enzymes at appreciable level for commercial use.
There were no appreciable differences compared to primary analysis (this alternative analysis is not reported).
Therefore, the results in this study provide an alternative method of achieving an appreciable CR rate with a reduced use of bortezomib.
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