Sentence examples for appreciable affinity from inspiring English sources
Taken together, these results suggest that 5-HT2A receptor antagonism may increase antipsychotic effects of typical APDs such as haloperidol, which lack appreciable affinity for the 5-HT2A receptor (Ichikawa and Meltzer 1999a; Meltzer 1999).
The TRIM5α-CA binding interaction requires an assembled capsid lattice, since individual CA monomers do not have an appreciable affinity for TRIM5α (Stremlau et al., 2006).
Lurasidone has little to no appreciable affinity for the 5-HT2C, H1standne H1, acetylcholineline M1 receptors.
The E545K oncogenic mutant therefore specifically binds to constitutively active Cdc42 with appreciable affinity compared with wild-type PI3Kα or the H1047R oncogenic mutant.
Gankyrin does not bind wild-type FtsH with any appreciable affinity (Supporting Information, Figure S2), which is unsurprising, given that the S6 and FtsH ATPase subdomains share only ∼24% sequence homology.
More recently, siderophores produced by certain Pseudomonas species were shown to bind exogenous transition metals other than Fe(III) with appreciable affinity [ 40, 41], thus invoking conditions of low internal iron.
A small amount of GO did not restrain the proliferation and viability of the mMSCs and PC12-L cells, which indicated appreciable cell affinity of GO.
By contrast, under the high ionic strength buffer conditions employed herein (200 mM NaCl), no appreciable Fpg affinity for the carba-8-oxo-dG substrate analog is detected.
On the basis of receptor-binding displacement assays in rat brain and glioma cells, 9 had appreciable binding affinity and displaced a prototypical PBR ligand, Ro 5-4864, wIC50IC50 values between 289 and 390 nM.
Additionally, a minor fraction of the PSOA mixture does displays appreciable sediment affinity which is anticipated to attenuate its toxicity and could increase its persistence in the aqueous environment.
