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Expression of HIF-1α was appraised using the modified semi-quantitative immunoreactive score (IRS) scale according to Remmele (Table 1) [ 10].
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Studies were critically appraised using the CASP appraisal tool.
Twelve publications were appraised using the Johns Hopkins Nursing Evidence-Based Practice Research Evidence Appraisal Tool.
Studies deemed eligible were appraised using the McMaster Critical Review Form.
Randomised trials will be appraised using the Jadad scale, 15 while non-randomised/observational studies will be appraised using the Newcastle-Ottawa scale, 16 and systematic reviews will be appraised using the Assessing the Quality of Systematic Reviews AMSTARR) criteria.
The methodological quality of the included studies was appraised using the COSMIN checklist [ 18].
The quality of evidence and grading of recommendations was appraised using the AGREE II tool.
The included studies were appraised using the seven-item Cochrane risk-of-bias tool.
Included studies were appraised using the process recommended by the Cochrane Qualitative Methods Group.
Studies will be critically appraised using the Critical Appraisal Skills Programme (CASP) Economic Evaluations checklist.
Quality was appraised using the revised American Society of Clinical Oncology Level of Evidence (LOE) scale for biomarker research [ 25].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com