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This latter finding was confirmed by a study applying vaccination using soluble recombinant gB in combination with an adjuvant MF59 and gB expressed by a recombinant canarypox virus [ 137], leaving the question concerning the relation between gB antibodies and autoantibodies open.
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The applied vaccination strategies, however, differed in detail from country to country [ 2].
We applied vaccination in patients after extensive distal embolization or embolization (proximal or distal) for a shattered spleen.
Therefore, new diagnostics will play a key role in decreasing the incidence of typhoid fever, by permitting governments to accurately assess the particular burden of disease and apply vaccination regimes accordingly.
Consequently, we apply vaccinations independently of each other and use average values for the age-dependent vaccine efficacy which does not consider pre-existing immunity.
The net returns (for the three sectors together) have a positive value for all vaccination strategies indicating that applying a vaccination strategy is better than doing nothing (Table 6).
Applying the vaccination driven hypothesis it would appear unlikely that ptxS1 variants different to ptxS1A will emerge, given the Australian WCV (ptxS1A) has been replaced by the use of ACVs containing non ptxS1A components.
For this reason, when applying this vaccination scheme, i.e. a single dose in the second year of life without an addition booster dose, it is important to have a solid surveillance programme, in which the number of patients with serogroup C meningococcal disease is carefully being monitored in order to determine long-term vaccine protection.
Cell numbers applied per vaccination and numbers of vaccination are given in Table S2.
They applied a vaccination campaign towards general practitioners with an increase in seasonal vaccination rate from 36%to63%3% and a pandemic vaccination rate of 85% [ 11].
Our findings may not apply to vaccination against seasonal influenza due to numerous differences in beliefs towards the vaccination.
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