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This outcome applied to both up- and down-regulated clusters of genes.
To investigate the difference between selecting GSTF pairs either on growth-based genetic interactions or similarity in DNA binding, hierarchical clustering was applied to both groups individually (Additional file 3).
We examined this issue based on the analysis of modules detected by network clustering methods applied to both integrated and individual (disaggregated) data sources, which we call interactome classes.
We compare the results of our Rec-BTP algorithm (applied to clusters from both AVDPM and SciClone) to the original clusters output from these algorithms over the 1000 randomly constructed BTPs for each of the seven tree topologies.
Dr. Hut thought the same concept could be applied to star clusters.
Remarkably, SDM applied to contaminated clusters is better able to recover masses than even the scaling relation approach applied to uncon- taminated clusters.
Hierarchical bi-clustering was applied to determine clusters in these matrices (see Materials and Methods for details).
An iterative clustering is then applied to generate the clusters.
Cluster analysis was applied to clusters 1 and 2 separately but no subclusters were evident.
According to our evaluation study [ 17], the method we developed [ 12] outperformed the others tested when applied to gene cluster data and both sensitivity and false discovery rate were taken into account.
> Both algorithms were applied to the cluster of co-expressed genes involved in translation (Cluster K1).
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