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Applying structure probing and NMR, we show that the RNA adopts the canonical rod-shaped 6S RNA architecture with little structure formation in the central bulge (CB) even at moderate temperatures (≤37 °C).
In particular, WS-HEQ II ( 2 ) behaves better than WS-HEQ II ( 1 ), whereas WS-HEQ I ( 2 ) behaves worse than WS-HEQ I ( 1 ), revealing that applying structure II can make WS-HEQ less costly in computation and can obtain improved recognition results simultaneously.
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By exploiting crystal structures of several complexes between CDK2 and inhibitors and applying structure-based drug design (SBDD), we rapidly discovered a very potent and selective CDK2 inhibitor 4-[ 5-isopropyl-1,3-thiazol-2-yl)amino] benzenesulfonamide (compound 4-[ 5-isopropyl-1,3-thiazol-2-yl
The design processes involve (i) choosing a starting modular interaction domain appropriate for the target and applying structure-guided modifications; (ii) attaching a second domain, termed "enhancer domain"; and (iii) optimizing the peptide-binding site located between the domains by directed evolution.
Future work applying structured expert judgement to questions of intervention effectiveness is needed to further refine the method.
To remedy the situation, we conducted extensive psychiatric evaluation of suicidal patients admitted to a psychiatric center in a metropolitan area of Japan by applying structured interviews.
It captures practical and sensible ideas and applies structure and rigor to the design.
Our completed work supports that the attempt to apply structure combination to discover more efficient neuroprotection lead compounds is viable.
We also apply structure learning techniques to identify functional relationships such as prey predator between trophic groups of species that vary across space and time.
Yeah, why apply science to it, why apply structure?
The method to the artworks' madness is present, but Pettibon never applies structure too closely, as he finds the beauty in broken rules.
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Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com