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In this report, we identified a new MAR element within the β-globin locus and observed the SATB1 mediated inter-MAR association by applying several approaches.
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For predicting genes, we applied several approaches: (i) Homology-based prediction: Proteins previously annotated in other species (Supplementary Table 9) were mapped to the genome using BLAT56 (Version 34) with default parameters.
We applied several approaches to statistically analyze the resulting data.
Thus, in order to identify precursors of genes and domains involved morphogenesis of animals, it is necessary to apply several approaches that can detect homologies even if sequences lack animal-specific domains [24] [25], [27].
We applied several approaches for reducing compositional bias and saturation in the phylogenetic analyses of the mitochondrial sequences.
The objectives were to: 1) analyse postglacial recolonization of whitefish in the region; 2) assess the evolutionary distinctiveness of NSH, and 3) apply several approaches for defining conservation units towards setting conservation priorities for NSH.
Because there are large differences in the nucleotide composition of mitochondrial sequences of different lineages as well as in the amino acid composition of the encoded proteins [ 42- 48], we applied several approaches for reducing compositional bias in the phylogenetic analyses.
We followed this reasoning in our study by applying several different approaches to measure association and agreement between physicians and patients.
This class of dynamical systems has been deeply investigated (with different levels of simplifications) applying several alternative mathematical approaches.
We have addressed this issue by applying several novel spectroscopic approaches to monitor motor dissociation, phosphate release, and nucleotide binding during processive movement by a dimeric kinesin construct.
Given the large number of pre-miRNA candidates that can be identified in single-genome approaches, even after applying several filters for precursor robustness and stability, a conventional structural clustering approach is unfeasible.
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