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The design is carried out applying robustness criteria for stability and performance.
In order to determine the robustness of the method a new set of DoE experiments was carried out applying robustness around the optimal conditions was evaluated applying a fractional factorial of resolution III with 11 runs, wherein additional factors – such as column temperature and quadrupole resolution – were considered.
Table 7 shows the improvements in WER as a result of applying robustness methods.
Several authors have introduced the visionary idea of applying robustness in drug development [ 9, 10, 23, 35], although the application of the general definition is still a key problem in Systems Biology.
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Lloyd applies a robustness analysis developed by Weisberg [39] that puts forward a robust theorem of the general form: ceteris paribus, if [common causal structure] obtains, then [robust property] will obtain.
The usual criteria apply: correctness, robustness, and elegance.
The screening designs applied in robustness tests are usually fractional factorial or Plackett Burman designs.
A Plackett-Burman design was applied for robustness testing, and a method control strategy was established.
Physicists apply a robustness analysis in testing this hypothesis, the argument goes.
Zhang et al. [35] applied the robustness to evaluate adaptability considering adaptable activities that may happen at three levels: the parameter, configuration and architecture.
The reliability refers to meeting standards of scientific plausibility, technical adequacy about data, methods used, analysis applied and robustness of conclusions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com