Sentence examples for applying pathway from inspiring English sources

We next set out to identify the canonical signaling pathways that possibly underlie tumor cell responses to arsenic trioxide by applying pathway analysis to the 209 differentially expressed genes (see Methods).

Elucidation of the biosynthetic pathway to pneumocandins is the first step in applying pathway manipulation and biocombinatorial chemistry approaches to engineer new derivatives with broader spectra of activity and improved physiochemical characteristics to meet the challenges of broader efficacy and clinical resistance.

Quantitatively, extrapolation across species can be illustrated by applying pathway-based benchmark concentration modeling in combination with the human reverse toxicokinetic modeling of Wetmore et al. (2012) to the flusilazole concentration-responsive retinol metabolism pathway of zebrafish embryos, described above.

To improve the utility of these approaches, we applied pathway analyses integrating both GWAS and gene expression.

To decrease redundancy, we applied pathway filtering to remove bulky pathways.

We applied pathway analysis as a complementary method of biological analysis of the gene groups generated by clustering.

We also applied pathway scores in another cohort of 233 individuals of European descent genotyped through the International Warfarin Consortium IWPCC).

Therefore, we propose a supervised method that applies pathway information to summarize similarity statistics to a consensus statistic that is more informative than any of the single measures.

Here, we applied pathway enrichment analysis of the bladder cancer SEN and found that it is enriched for genes that have strong associations with benzo[ a]pyrene.

The P-values and FC values for all peptides can be found in Additional file 3. We have previously applied pathway over-representation analysis (ORA) to kinome data to infer cellular responses from the standpoint of signaling networks [ 23, 24].

Applying the same analysis in T2DM patients versus controls, we also detected significant metabolic differences, albeit at lower levels of statistical significance, due to the low number of controls.> To obtain more insight into the pathology behind the differences in gene expression, we applied pathway analysis using Gene Set Enrichment Analysis (GSEA, [ 23]).