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Nevertheless, we recognized that there may have been misclassification of deaths among those lost to follow-up and we attempted to correct for this bias by applying an assumption that 30% of these patients were deceased, based on findings from our own previous tracking study, and a similar analysis at a relevant local Ugandan setting.
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The formula for estimating the value of the interruption of STI transmission in the population applies an assumption that each case treated prevents 0.5 cases of that STI in the population.
This allows flux determination based solely on reaction stoichiometry and thermodynamics from the EMs generated by EMA, rather than applying a metabolic assumption (maximizing growth rate) in optimization based studies (such as FBA).
By applying a few assumptions, a simplified method has been developed.
Further, applying an extraction efficiency assumption of 14% [ 45] to the qPCR data at 21d post-hatch where ca. 100 C. perfringens group rRNA gene copies were observed ng−1 of DNA, gives 2.8 × 10 cells g−1 of cecal contents, or 0.028% of a total bacterial community of 10 cells.
To account for the potentially conservative estimates of commuting cycling undertaken when cycling was selected alongside other modes (see table 1), by way of sensitivity analysis we applied an alternative assumption that commuter cycling was done for 30% (rather than 10%) of these journeys.
And, when applying a more plausible assumption of a latency of 10 or more years, the EBRT group would have to have had 63 % higher asbestos exposure than the comparison group in order to fully explain the observed association between EBRT and mesothelioma.
We applied a conservative assumption that the overall cost savings were zero.
Consequently, we applied a favourable assumption that the treatment effect in Lujan et al. is the fall in HbA1c in the treatment arm between baseline and follow-up (0.45%).
For instance, in the Chay-Keizer model discussed in Section 3.2.1, the branch of periodic solutions near the left-most Hopf bifurcation is very steep, in both the full system and the reduced system obtained by applying a quasi-steady-state assumption (see Figure 1).
NPRS relaxes the molecular clock assumption by applying a least squares smoothing of estimates of substitutions rates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com