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This is in agreement with an ovine animal model [ 49], which also used sheep mammary gland epithelial cells to identify molecular mechanisms that are affected by selection for high and low SCS in two divergent lines of sheep selected by applying a selection strategy based on conventional breeding values.
A common framework to select the most important set of features is provided by applying a selection threshold.
Recently, Doyle and colleagues demonstrated that highly specific ligand receptor pairs can be engineered in a rapid fashion by creating large libraries of protein variants and applying a selection scheme to identify variants with improved activation by the target synthetic ligand.
It's an evolutionary inevitability that resistance will build up at some point, [because] we're applying a selection pressure, and the pests will respond".
By applying a selection based on in vivo protein-protein interaction assays of compounds from a combinatorial chemical library followed by virtual screening, we have developed small molecules that efficiently antagonize the Ubc13-Uev1 protein-protein inhibitingn, inhibitheg thenzymaticic activity of the heterodimer.
The defining feature of adaptive evolution involves applying a selection pressure that favours the growth of mutants with the traits of interest.
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A practical approach is to apply a selection technique to select a smaller set of relevant genes from the entire gene set as initial step; a dimensionality reduction technique is then applied to the selected gene set [ 15].
Because the space of possible configurations isquite large, we applied a selection procedure to pick the most "distinctive"value set.
We also apply a selection criterion based on the Kp index to keep data corresponding to a global low level of geomagnetic activity.
However, since our data set solely contains finally defaulted borrowers, we do not see any way for us to apply a selection model here.
In this work, we applied a selection pressure to restore the original phosphotriesterase activity.
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