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If neither research and development expenditures nor total revenues were listed by product (n = 5), we then took the product-specific proportion of revenue from the earliest year available and applied this proportion to total research and development spending for all previous years.

Applying this proportion to the WPR-A stratum we estimate that 1050 suicides are due to pesticide poisoning.

We then applied this proportion to the number of projected cases in the post-treatment monitoring and long-term survivor phases in 2008 2017.

By applying this proportion to the estimated number of satisfactory tests, we estimate that 153,393 women have a positive result (Table 3).

This approach relied on the estimated proportion of cases that were hospitalized or died, as determined from surveillance data or reported in the literature, and applying this proportion to the total estimated number of laboratory-confirmed or hospitalized cases.

These incidences were extrapolated from the available data by calculating the known Ontario and Australian incidences as a proportion of the Connecticut rates and applying this proportion to the Connecticut data for the missing years.

We applied this proportion to the entire US population aged 18+ using 2012 census data as the denominator, excluding Medicare FFS beneficiaries using Centers for Medicare and Medicaid Services-reported estimates.

We then applied this proportion of late entry into care to patients diagnosed in the years following 2007 to obtain an estimate of the total number of patients entering late in care.

We applied this proportion to US census data for that age group, year, and FoodNet site and summed values from all laboratories to obtain an age-group denominator for 2003 2009.

For physicians, estimates from the NSS survey suggest that 37% (63% in rural and 20% in urban areas) had inadequate or no medical training; applying this proportion to the Census estimates, the allopathic physician density in India reduced from 6.1 to 3.8 per 10 000 population.

By applying this proportion of re-entry to the patients not retained in care in the following years and then subtracting those already re-entered in care, we estimated that 940 persons were expected to re-enter in care after 2011 (see detailed computation in Additional file 1).

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