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To apply the gene expression profile in clinical practice, we will need to improve the predictive ability of the profile and confirm the reliability of survival profile in a prospective multi-center study.
The measurement bias exhibited in COSMIC can be further examined when whole genome sequence data repositories for cancer [ 20] become sufficiently populated to apply the gene maximum multiplicity measure.
In yeast, where the notion of expression breadth does not apply, the gene expression level and protein evolution rate are strongly and negatively correlated (Drummond et al. 2005; Wall et al. 2005).
We also apply the gene harvesting method proposed by Hastie et al. (2001) and discussed by Segal (2006) [ 7, 26] to the simulation data, but don't show the results in Table 2.
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Recently, scientists try to apply the gene-editing techniques to human germ cells and embryos, hoping to prevent the transmission of inherited diseases to the next generation in the future.
To apply the gene-neutral classifier to the real-world task of annotating mentions of any gene in cancer trial documents, we generated a set of 4,031 annotated gene instances (including 249 distinct gene symbols) from 250 randomly selected trial documents.
After applying the gene filtering steps, a total of n = 3,364 genes were selected for the microarray predictor building and testing.
Applying the Gene Characterization Index to genes within pharmaceutically relevant classes, we confirmed known drug targets as high-scoring genes and revealed potentially interesting novel targets with low characterization indexes.
We extended the functional analysis of our signature applying the gene set enrichment procedure on GO.
Figure 7 presents the decrease in mean accuracy by applying the gene lists to separate studies.
To further extend the substantial gene content on chromosome 6B, we applied the gene models from the survey sequence data [ 15].
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