Potential HEAT repeats in each sequence are identified using REP without an applied confidence threshold.
A more detailed assessment of the interactions can be performed by applying confidence measures as described below.
Applying confidence scores, checking the literature references listed in SignaLink or using other evaluation tools could help the users to filter the most probable interactions for their analysis.
Evaluations of phylogenetic procedures are typically performed by two different means: the most commonly applied confidence measure in phylogenetics is non-parametric bootstrapping.
Therefore, it is generally required to apply data confidence criteria such as the presence of well-defined activity measurements or evidence for direct ligand-target interactions (as provided in ChEMBL as activity data filters).
Results give confidence to apply the illustrated approach in academic and industrial settings, namely for optimizing equipment operation.
In calculating this we assumed a headache prevalence of 50% and applied a confidence level of 99% and confidence interval (CI) of 2%.
We assumed, without guiding data, a headache prevalence of 0.5 (50%) and applied a confidence level of 99% and confidence interval of 2% in calculating the necessary sample size.
Hence, the cLRT may be applied with confidence in many situations.
With this proof, the useful model of Stone can be applied with confidence to a wide range of situations.
