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They stated that it was often difficult to judge when to apply a restraint.
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To facilitate configurational sampling, we applied a weak restraint whose score depended linearly on the distance between cross-linked residues, with a slope of 0.01 Å−1.
For similar reasons, in the second reaction step (hydrolysis of the alkyl enzyme intermediate; Figure 1 ) it was necessary to apply a weak (3 kcal·mol–1·Å–2) distance restraint between the oxygen atom of the hydrolytic water molecule and the Cγ atom of D105 and between the water hydrogen and the proton acceptor (Nε2 or Oδ1 for H300 and E35, respectively).
Axial and rotational restraints were applied by a restraint beam.
He modernized the police, applied a policy of restraint that spared New York the tragic shootings that occurred elsewhere, and left the city the sixth safest of the top 25 cities in F.B.I. statistics.
Veteran director Robert Wise masterfully orchestrates tools of the trade to create perhaps the quintessential filmed ghost story, applying a degree of restraint and subtlety generally absent from more modern horror entries.
The MD simulation for all the modeled complexes was ∼120 ns and was completed by applying a soft harmonic restraint on the HA backbone atoms (Cα, N, and carbonyl carbon) with a harmonic constant of 2.0 kcal mol 1.
He suggested that Labour would apply pay restraint in a more flexible manner than the government.
In December, a grand jury declined to bring charges against NYPD officer Daniel Pantaleo, who applied the chokehold – a restraint tactic banned by the department – that led to Garner's death.
It was a pleasure to see him apply the same restraint to a jersey harness dress as to a pale pink suit with a matching draped blouse and a slit skirt.
"In a stagnating economy, the unions have been urged to apply wage restraint.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com