Most integrations are also subject to site-specific genomic position effects that can diminish or alter transgene expression, making functional comparisons unreliable, and the creation of strains having optimal transgene expression for applied use unnecessarily difficult (Horn et al. 2000; Schetelig et al. 2009a).
This research attempts to explore the efficiency and effectiveness of a GA, when applied to a difficult design task, without being unnecessarily constrained by preconceptions of how to solve the task.
A randomised methodology was not applied for pragmatic reasons because clinical teams did not wish to unnecessarily delay treatment.
Thus, neither forcePos nor rma was applied as pre-processing for any of those two methods to not unnecessarily modify the values in artificial ways.
Don't close credit cards once they are paid off and don't apply for credit cards unnecessarily.
Women could run for office, he said, especially once they were past their childbearing years and their wisdom could be applied outside the home, just as long as everybody avoided looking at each other unnecessarily at council meetings.
These space-invariant methods are applied uniformly throughout the whole image, that is, apart from the noisy pixels, they unnecessarily change the noise-free pixels and impair image details.
If the results of the UK trials had been applied as a guide to treatment, only 2% of the women would have received anti-RhD immunoglobulin unnecessarily, compared with 38% in the absence of genotyping.
It may cause us to overlook model specification problems, to unnecessarily and inappropriately change our theories, and to miss out on information that could be usefully applied to the specification and estimation of our model.
Since the whole model is unnecessarily too complex for the purpose of testing the xDriver system, some modifications have to be applied to it.
