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Sequence and structure data were applied to study the role of the first oxyanion hole residues.
It appears a larger sample size and a more sensitive method should be applied to study the role of this cytokine in T1D.
Knockout, conditional knockout and gain of function (transgenic) approaches applied to study the role of Jun and Fos proteins during development and in diseases.
Here a similar approach has been applied to study the role of metabolism in hypoxia, using a non-targeted metabolite profiling approach to gain a global profile of the metabolome of each sample (via. cell-environment interaction).
In particular, combinations of two- and three-dimensionally engineered substrates with lipid membranes have been applied to study the role of simple membrane geometries on membrane interacting protein networks in vitro (Schweizer et al., 2012; Zieske and Schwille, 2013).
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A "systems-based candidate-gene" approach based on NetKO could provide a powerful approach to apply "a posteriori" biological knowledge to study the role of epistasis in disease.
A third model, the Social Network Theory SNTT) as applied to health was added to our conceptual framework to study the role of family and social environment.
In order to study the role of disease-associated microRNAs in pathways, we applied a thorough statistical analysis to a multipartite graph consisting of microRNAs, proteins, diseases, tissue and signaling pathways.
TMS has already been used to study the role of the dorsolateral prefrontal cortex (DLPFC) in decision-making applying TMS before subjects did the Ultimatum Game [24], [25].
To study the role of MGs as magnetoreceptors, we examined under confocal microscope size fluctuation of MGs in trophocytea when additional magnetic field (1 Gauss) was applied.
This approach could be applied to study functional roles of mitochondria DNA damage repair protein complexes.
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