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In this paper DoE has been applied to fed simulated gastrointestinal media consisting of eight components (pH, bile salt, lecithin, sodium oleate, monoglyceride, buffer, salt and pancreatin) using a two level D-optimal design with forty-four duplicate measurements and four centre points.
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In this work, a model-based optimization methodology that uses experimental feedback is applied to a fed-batch bioreactor.
This estimation method is illustrated with an academic example and then applied to a fed-batch bioprocess.
This work presents a production optimization approach with operating constraints applied to a fed-batch penicillin process with a DMC predictive controller.
The Bayesian inference based two-stage support vector regression (BI-SVR) approach is applied to a fed-batch penicillin cultivation process and the obtained soft sensor performance is compared to that of the conventional SVR method.
This work presents a novel tuned approach of the Generalized Predictive Control controller in both adaptive and nonadaptive configurations applied to a fed-batch penicillin process using the complete factorial design method.
The scheme is applied to a nonlinear fed-batch fermentation process.
Estimates are that it will cost $3.2 billion, and Florida applied to have the feds pick up $2.6 billion of the tab.
The proposed methodology is applied to an inverter-fed induction motor during a start-up followed by a steady-state regime, where it is verified its capability to identify a single broken rotor bar, mixed eccentricity in the form of motor-load misalignment, and the combination of both faults.
Subsequently, the pump was successful applied to carry out anaerobic fed-batch fermentations of Saccharomyces cerevisiae in the microreactor system for periods up to 20 h.
In this work, neural filtering and control have been applied to such a nonideal fed-batch bioreactor containing recombinant Escherichia coli to produce β-galactosidase.
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