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Our results show the utility of combining focused small molecule derivation, applied to a biological screen using the zebrafish model, to identify new compounds with desired target activity and specificity.
Response to interventions applied to a biological system can be predicted using SEM.
Further, our method has been applied to a biological problem of validation of metabolic pathways in an organism lacking good-quality metabolic reconstruction, namely Trichoderma reesei.
It is only one of the components of -omics approaches which - when fully applied to a biological problem - will generate a composite picture of biological processes.
To illustrate how logic-based modeling can be applied to a biological network, consider a hypothetical representation of epidermal growth factor receptor (EGFR) 1 and several downstream proteins.
Applied to a biological data set obtained from Arabidopsis root development, the model reveals the dynamic organization of network components.
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Here, we explore for the first time how this approach can be applied to a specific biological system, the human kinetochore, which is a multi-protein complex involving over 100 proteins.
Nagel's model was revised and applied to a specifically biological context the reduction of classical genetics to biochemistry by Kenneth Schaffner (1967, 1969, 1976; see Schaffner 1993 for his mature account).
Existing antibody applied to a new biological system; new organism/tissue/cell type.
Overall, this work demonstrates that our method, when applied to a particular biological process, is capable of providing a comprehensive picture of the role of phosphorylation in that process.
Misconceptions are not inherently inaccurate, but rather are inappropriately or incompletely applied to a given biological context in a way that is not aligned with our current scientific understanding of the world (Leonard et al., 2014).
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