Since 2004, with the support of the national special fund, NIFDC created the key technology system for the development and evaluation of the vaccine and has successfully applied this system to the development of H5N1 and H1N1 human avian influenza vaccines.
To evaluate the feasibility and practical merits of combined the controlled SERS-active nanostructures with the Raman technique, we applied this system to various aspects of cell-based research.
Finally, we applied this system to the entirety of three PLOS journals to extract all known human gene gene interactions.
For example, Cook and colleagues [ 34] have applied this system to the detection of six different cytokines at the protein level in tears from allergic patients.
We have applied this system to analyze control of molting by nuclear hormone receptors and meiosis-specific roles for proteins required for germline proliferation, demonstrating the versatility of this system for dissecting protein function in a widely used model organism.
We applied this system to evaluate the action mechanism of patulin, one of the most potent mycotoxins, and found that patulin targets proteins and possibly DNA [ 7].
In addition, we have further applied this system for screening and identification of the highly effective siRNAs that could specifically inhibit expression of mouse matrix metalloproteinase-7 (MMP-7), Epstein Barr virus (EBV) latent membrane protein 1 (LMP1), and human serine/threonine kinase AKT1.
We further applied this system to show that transient coexpression of α-synuclein inhibits the proteasome activity of SH-SY5Y cells.
To understand how specific DNA and chromatin elements contribute to the functional organization of the genome, we developed a new tool the tagged chromosomal insertion site (TCIS) system to identify and study minimal DNA sequences that drive nuclear compartmentalization and applied this system to specifically study the role of cis elements in targeting DNA to the nuclear lamina.
UEFA is applying this system of competition as a chance for smaller countries to advance to the European Championship Finals," he said.
