Our ability to synthesize our understanding of this ecosystem to answer basic and applied questions is hampered by the lack of sufficient data for many taxonomic groups, which stems from three main constraints: sampling biases/issues, life-history characteristics of target species, and the lack of trained taxonomists, especially in economically unimportant groups.
While the presentation of protein drugs in form of nanoparticles is in general advantageous regarding correct biodistribution, this principle might not apply to brain targeting that is hampered by particular bio-physical barriers.
Electrotherapeutic units of low voltage may produce currents of intensities up to a few microamperes and milliamperes, but measuring the current distribution of an applied electric current in biological tissues is hampered by several factors.
Applying MRI procedures to small children is hampered by the combination of patient noncooperation, rapid or irregular respiratory rate, and small-scale anatomy, meaning that very small movements can create motion artifacts that render images non-diagnostic.
However, the promise of applying these gene signature biomarkers in clinic is hampered because the underlying biology of gene signatures in cancer development is not well understood.
However, like all rodent models, the use of the MC4R-KO mouse is hampered by certain limitations that do not apply to fish models of this disease.
Unfortunately, the broad application of 3D imaging and image analysis is hampered by difficult-to-apply protocols (Godoy et al. 2013).
However, comparison of findings with other studies is hampered by the fact that different measures for socio-economic status have been applied, including education, income or occupation [ 54].
When Brownian relaxation is hampered, immobilized multicore MNP own a higher coercivity than single core MNP and the applied field strength might be too low to exploit the SAR of such ferrimagnetic MNP within the investigated samples.
Progress is hampered by insufficient numbers of PCR-compatible co-dominant markers that can be used readily in applied breeding programmes.
