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With the present study including subgrouping (e.g., by DNA methylation arrays), FISH or MLPA to detect monosomy 6, and Sanger sequencing of CTNNB1 (exon 3), we aim to provide a rationale as to which of these markers should best be applied in a clinical study setting.
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However, such an approach has rarely been applied in a clinical setting to study constitutional deletions.
In our institution, both the abovementioned methods were prospectively applied in a clinical phase I pretargeted RIT study in 20 patients with advanced colorectal cancer [11].
This analogue has already been applied in a therapeutic clinical study [ 26].
But further clinical research is needed to see if the findings can be applied in a clinical setting, Hallstrom added.
We subsequently applied the methods in a clinical study of DNA samples from newborn infants with or without NTDs.
Furthermore, biomarker adaptive designs can be applied in one clinical study to identify the most suitable target subgroup, based on clinical observations or known biomarkers, and to evaluate the effectiveness of the treatment in the patient subgroup [ 11– 15].
Applying mbRSA for evaluation of FAI hips in a clinical study could provide further insight of the in-vivo pathomechanics of FAI and the mechanisms causing pain.
In a clinical study, the metabonomics method was applied to study clinical urine samples in patients with suboptimal health with different syndromes [ 6].
Both sites added staff and were provided broad research training, and these new skills were immediately applied in a rigorous clinical research study.
The Youden index has been successfully applied in many clinical studies and served as an appropriate summary for the diagnostic accuracy of a single quantitative measurement (e.g., [ 2, 6, 7]).
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