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In a previous study they injected QDs subcutally- mimicking the penetration of 100% of an applied dose (48 pmol QDs)- and found only 6% of the applied dose in the liver and 1% in the regional draining lymph nodes [ 46].
Silver depth concentration profiles measured using AES show correlation between applied dose and surface chemical composition.
Only one method (medication weight) takes into consideration the applied dose.
Total absorption was 72% of the applied dose with rats and 60% with humans.
The efficacy was positively correlated (correlation co-efficiency: 0.9526 0.9873, P < 0.05) to the applied dose of each active component.
Uptake of Ag in HEK was <4.1% of applied dose with proteins suppressing citrate, but not silica coated Ag uptake.
Both equimolar suspensions and saturated solutions in 30% ethanol/pH 7.4 buffer were employed as the applied dose.
In the absence of data, consumer exposure is based on relevant habits and practices and assumes 100% skin uptake of the applied dose.
In our study, the applied dose modulation (CARE Dose 4D™) was used with an average adaptation to patient BW.
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The toxicities of the applied dose-intensive cisplatin therapy plus low-dose VP16 are mainly related to neurotoxicity, ototoxicity, haematologic and GI toxicity.
Based on the same trial design, another group applied dose-escalated doxorubicin at 75 mg m−2, with a 32% response rate (Dirix et al, 1994).
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